Frontiers | From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS) | Protocol
A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by
Frontiers | From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
a) PROTAC-mediated ternary complex formation and Hook effect as a... | Download Scientific Diagram
Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs - ScienceDirect
Characterizing PROTAC ternary complex formation using Biacore SPR systems | Cytiva
Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras | Science Advances
PROTACs: Current Trends in Protein Degradation by Proteolysis-Targeting Chimeras | BioDrugs
Protein Degraders | Targeted Protein Degradation | Bio-Techne
PROTAC-mediated ternary complex formation and hook effect. The hook... | Download Scientific Diagram
Accelerating PROTAC drug discovery: Establishing a relationship between ubiquitination and target protein degradation
Proteolysis‐targeting chimeras in drug development: A safety perspective - Moreau - 2020 - British Journal of Pharmacology - Wiley Online Library
Mechanistic and Structural Features of PROTAC Ternary Complexes | SpringerLink
Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins | Journal of Medicinal Chemistry
Pharmaceutics | Free Full-Text | A Mechanistic Pharmacodynamic Modeling Framework for the Assessment and Optimization of Proteolysis Targeting Chimeras (PROTACs)
a) PROTAC-mediated ternary complex formation and Hook effect as a... | Download Scientific Diagram
An AURKA PROTAC cocktail relieves the hook effect. A) Scheme depicting... | Download Scientific Diagram
PROTAC-mediated ternary complex formation and hook effect. The hook... | Download Scientific Diagram
Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects | Medicinal Chemistry Research
Frontiers | From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
The Power of PROTACs - LifeSensors
Pharmaceutics | Free Full-Text | Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs
Targeted protein degradation in cancers: Orthodox PROTACs and beyond. - Abstract - Europe PMC
Biomolecules | Free Full-Text | Central Nervous System Targeted Protein Degraders
Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs - ScienceDirect
